Abcam, ab142808, T0901317, LXR agonist

Size: 10mg / 50mg
MW 481.3 Da, Purity >99%. Potent, non-selective LXR agonist (EC 50 = 50 nM). Increases ABCA1 expression associated with cholesterol efflux regulation and HDL metabolism. Increases muscle expression of PPAR-δ. Shows antiobesogenic effects in vivo. .
Key facts
CAS number:293754-55-9,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:481.3 Da,
Molecular formula:C17H12F9NO3S,
PubChem:447912,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 100mM,
Biochemical name:N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide,
Biological description:Potent, non-selective LXR agonist (EC50 = 50 nM). Increases ABCA1 expression associated with cholesterol efflux regulation and HDL metabolism. Increases muscle expression of PPAR-δ. Shows antiobesogenic effects in vivo.,
Canonical smiles:C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O,
InChi:InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2,
InChiKey:SGIWFELWJPNFDH-UHFFFAOYSA-N,
IUPAC Name:N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Glucocorticoid Receptor (GR) LXR alpha Androgen Receptor (AR) PXR Retinoid X Receptor alpha (RXRA) ROR alpha (RORA) ROR gamma LXR beta (NER) and G-6-Pase form a diverse group of nuclear receptors and enzymes. These proteins often share a function in regulating gene expression in response to ligands. Glucocorticoid Receptor Androgen Receptor and Retinoid X Receptor alpha are prominent members in steroid and xenobiotic sensing. Masses for these proteins vary with Glucocorticoid Receptor typically around 97 kDa. These targets express in various tissues; GRs in liver musculoskeletal and immune tissues ARs commonly in reproductive tissues while LXRs and RXRAs are seen in liver and adipose tissue. Together they serve as sensors and regulators in numerous physiological processes.
Biological function summary
These receptors control pathways related to lipid metabolism immune regulation and homeostasis. GRs engage in the stress response by modulating anti-inflammatory effects. The Liver X Receptors (LXR alpha and beta) activate genes involved in cholesterol efflux and lipogenesis. Retinoid X Receptor alpha plays a partnering role forming heterodimers with other receptor types enhancing their transcriptional activity. The Glucose-6-Phosphatase (G-6-Pase) is key in glucose homeostasis integral to gluconeogenesis and glycogenolysis processes. These proteins act both independently and as part of larger complexes intertwined in regulating metabolic health.
Pathways
Each target integrates into broader networks essential for maintaining cellular equilibrium. GR activity links to the hypothalamic-pituitary-adrenal (HPA) axis impacting stress hormone secretion and skin and bone health. LXR signaling pathway involves cholesterol homeostasis and inflammation closely associated with RXRA and its ability to form heterodimers. The Androgen Receptor functions in pathways related to reproductive organ development and is also tied to Prostate Specific Antigen regulation. RORs contribute to circadian rhythm modulation interlinked with genes mediating immune function and energy homeostasis weaving together different physiological threads.
These targets play significant roles in various conditions. Dysregulation of Glucocorticoid Receptor has links to conditions like Cushing's syndrome and autoimmune diseases due to disrupted immune response. Defective LXR signaling can contribute to atherosclerosis as impaired cholesterol transport and inflammation occur. Mutations or alterations in the Androgen Receptor often connect to prostate cancer development. In glucose metabolism impaired G-6-Pase function leads to glycogen storage disease (Von Gierke disease) emphasizing its importance in metabolic disorders. Understanding their roles at a molecular level offers potential for targeted therapies across a spectrum of diseases.