Abcam, ab14338, Anti-Thymosin beta 10 antibody

Size: 50µL
Rabbit Polyclonal Thymosin beta 10 antibody. Suitable for ELISA and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human TMSB10 aa 1 to C-terminus conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TMSB10 aa 1 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P63313,
Specificity:Human Thymosin B10 (aa 38-43). No cross reactivities with human Thymosin B4, Thymosin B9, Thymosin B15, Thymosin B4 (aa 1-4) peptide, or Thymosin B4 (aa 1-14).

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Thymosin beta 10 also known as TMSB10 is a small protein that plays a role in the dynamics of the cytoskeleton. It has a mass of approximately 5 kDa. TMSB10 is found in various tissues with high expression levels in the brain kidney and heart. Its function involves binding to actin monomers preventing polymerization and consequently regulating actin filament assembly in cells.
Biological function summary
TMSB10 significantly influences cell movement and proliferation. It serves as an actin-sequestering protein and is not generally part of a larger protein complex. TMSB10 promotes cell motility and plays an essential part in processes like wound healing and angiogenesis. Through these actions it helps in tissue regeneration and repair influencing the cell's structural organization and signaling.
Pathways
TMSB10 is involved in the actin cytoskeleton pathway and cellular signaling pathways that govern movement and shape changes in cells. Its interaction with actin places it in relation to actin-related protein (ARP) complexes such as Arp2/3 which facilitate actin filament branching. In addition TMSB10's regulation of actin dynamics links it to pathways involving proteins like cofilin which modulates actin filament turnover.
TMSB10 shows a connection to cancer and cardiovascular disorders. Elevated levels of TMSB10 have been associated with tumor progression due to its role in enhancing cell movement and metastasis. In cardiovascular disorders changes in TMSB10 expression can impact cardiac function due to its influence on actin dynamics. Proteins such as vascular endothelial growth factor (VEGF) interact with TMSB10 during pathological conditions further illustrating its role in disease mechanisms.