Abcam, ab143597, Corticosterone, endogenous steroid hormone

Size: 50mg
MW 346.5 Da, Purity >98%. Potent endogenous glucocorticoid and mineralocorticoid receptor agonist (EC 50 = 20 nM, GR). Induces apoptosis. Modulates carbohydrate, potassium, and sodium metabolism in vivo . Blood-brain barrier permeable.
Key facts
CAS number:50-22-6,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:346.5 Da,
Molecular formula:C21H30O4,
PubChem:5753,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 10 mM,
Biochemical name:Corticosterone,
Biological description:Potent endogenous glucocorticoid and mineralocorticoid receptor agonist (EC50 = 20 nM, GR). Induces apoptosis. Modulates carbohydrate, potassium, and sodium metabolism in vivo. Blood-brain barrier permeable.,
Canonical smiles:CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O,
Isomeric smiles:C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O,
InChi:InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1,
InChiKey:OMFXVFTZEKFJBZ-HJTSIMOOSA-N,
IUPAC Name:(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Glucocorticoid Receptor (GR) Progesterone Receptor (PR) Mineralocorticoid Receptor (MR) Gli3 Androgen Receptor (AR) Nrf2 SHBG Cortisol Binding Globulin and SLC22A3/OCT3 are important molecular targets in various biological processes. The Glucocorticoid Receptor also known as NR3C1 has a molecular weight of approximately 97 kDa and is expressed in almost all cell types. GR acts as a transcription factor and regulates genes linked to inflammation immune response and metabolism. Progesterone Receptor and Androgen Receptor part of the steroid hormone receptor family are primarily expressed in reproductive tissues. Gli3 involved in limb and brain development acts as a transcriptional regulator. Nrf2 responsible for antioxidant responses binds to ARE in the DNA controlling detoxification genes. SHBG a glycoprotein of about 90 kDa is produced in the liver and transports sex steroids. Cortisol Binding Globulin with similar transport roles primarily binds cortisol in the bloodstream. SLC22A3/OCT3 is a transporter protein involved in organic cation uptake.
Biological function summary
These proteins are important for mediating responses to endogenous steroid hormones and other signaling molecules. GR PR and AR as part of steroid hormone receptor complexes influence gene transcription by directly interacting with DNA. Gli3 operates as part of the Hedgehog signaling pathway important for cellular differentiation. Nrf2 forms a complex with KEAP1 that regulates oxidative stress responses by modulating gene expression. SHBG and Cortisol Binding Globulin maintain the bioavailability of steroids in the circulatory system influencing their biological effects. SLC22A3/OCT3 is involved in neurotransmitter clearance influencing cellular uptake transportation processes.
Pathways
These proteins interact in diverse signaling cascades that influence cellular and systemic functions. GR and MR are critical components of the hypothalamic-pituitary-adrenal (HPA) axis tightly regulating cortisol metabolism including corticosterone function and solubility. Nrf2 is central to the NFE2L2 pathway mitigating oxidative damage by controlling antioxidant genes. PR and AR are key in reproductive hormone pathways that drive sexual differentiation and function often interacting with proteins like Estrogen Receptor. SLC22A3/OCT3 interfaces with monoamine neurotransmitter pathways relevant to neural function and behavior.
Aberrations in these targets are linked to a variety of conditions. Dysregulation of GR is associated with stress-related disorders such as Cushing's syndrome and Addison's disease which involve altered cortisol and corticosterone hormone dynamics. Nrf2's role in oxidative stress links it to neurodegenerative diseases like Parkinson's. AR mutations relate to prostate cancer with cross-talk between AR and proteins like FoxA1 exacerbating disease progression. Abnormalities in SHBG levels are implicated in metabolic syndrome impacting insulin sensitivity and glucocorticoid binding globulin levels can influence autoimmune conditions due to altered corticosteroid regulation.