Abcam, ab144070, L-threo-Dihydrosphingosine (Safingol), lyso-sphingolipid PKC inhibitor

Size: 5mg
MW 301.5 Da, Purity >98%. Cell-permeable, reversible lyso-sphingolipid protein kinase C (PKC) inhibitor (IC 50 = 40 μM). Anticancer agent. Potentiates effect of D oxorubicin (DOX) (ab120629) in tumor-bearing animals and cytotoxicity of Mitomycin C (ab120797) in cancer cells. Active in vivo and in vitro .
Key facts
CAS number:15639-50-6,
Purity:>98%,
Molecular weight:301.5 Da,
Molecular formula:C18H39NO2,
PubChem:3058739,
Nature:Synthetic,
Solubility:Soluble in ethanolSoluble in DMSO to 5 mM,
Biochemical name:Safingol,
Biological description:Cell-permeable, reversible lyso-sphingolipid protein kinase C (PKC) inhibitor (IC50 = 40 μM). Anticancer agent. Potentiates effect of Doxorubicin (DOX) (ab120629) in tumor-bearing animals and cytotoxicity ofMitomycin C (ab120797) in cancer cells. Active in vivo and in vitro.,
Canonical smiles:CCCCCCCCCCCCCCCC(C(CO)N)O,
Isomeric smiles:CCCCCCCCCCCCCCC[C@@H]([C@H](CO)N)O,
InChi:InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18-/m0/s1,
InChiKey:OTKJDMGTUTTYMP-ROUUACIJSA-N,
IUPAC Name:(2S,3S)-2-aminooctadecane-1,3-diol

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months