Abcam, ab144211, Bisindolylmaleimide X hydrochloride (Ro 31-8425), PKC inhibitor

Size: 1mg / 5mg
MW 461 Da, Purity >98%. Potent, cell-permeable, reversible, ATP-competitive, and selective PKC inhibitor (IC 50 = 15 nM, rat brain PKC). Blocks antigen driven, but not IL-2 induced, T-cell proliferation. Shows less potent apoptotic effects than Ro-31-8220 (ab120374).
Key facts
CAS number:131848-97-0,
Purity:>98%,
Molecular weight:461 Da,
Molecular formula:C26H25ClN4O2,
PubChem:11539879,
Nature:Synthetic,
Solubility:Soluble in ethanolSoluble in DMSO,
Biochemical name:Bisindolylmaleimide X hydrochloride,
Biological description:Potent, cell-permeable, reversible, ATP-competitive, and selective PKC inhibitor (IC50 = 15 nM, rat brain PKC). Blocks antigen driven, but not IL-2 induced, T-cell proliferation. Shows less potent apoptotic effects than Ro-31-8220 (ab120374).,
Canonical smiles:CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN.Cl,
InChi:InChI=1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H,
InChiKey:IMBOYWXMTUUYGZ-UHFFFAOYSA-N,
IUPAC Name:3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione;hydrochloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months