Abcam, ab14425, Anti-beta Defensin 1 antibody [M11-14b-D10]

Size: 50µg
Mouse Monoclonal beta Defensin 1 antibody. Suitable for ELISA, WB, IHC-P and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human DEFB1 aa 1-50.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:M11-14b-D10,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DEFB1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P60022

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein L, Storage buffer-pH: 7.4Constituents: 0.79% Tris HCl, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Beta Defensin 1 also known as DEFb-1 is an antimicrobial peptide with a mass of approximately 4.8 kDa. This defensin emits from epithelial cells across various tissues such as the respiratory tract urogenital tract and skin. It forms part of a family of small cysteine-rich cationic proteins. The defensin microenvironment allows it to disrupt microbial cell membranes providing immediate defense against pathogens.
Biological function summary
This defensin protein plays an important role in the innate immune system by protecting epithelial surfaces from infection. DEFb-1 does not act as part of a larger protein complex and it independently modulates immune responses. Its expression helps maintain a balanced relationship between the host's immune system and microbial populations reducing inflammatory reactions.
Pathways
The action of beta Defensin 1 integrates into the Toll-like receptor signaling and NF-kB pathways. It participates in regulating the immune response against microbial invasion. These pathways involve interactions with proteins like MyD88 and TRAF6 linking beta Defensin 1 to the broader network of innate immunity.
DEFb-1 has associations with conditions such as inflammatory bowel disease and cystic fibrosis. In inflammatory bowel disease the reduced expression of beta Defensin 1 can disrupt gut microbiota balance while in cystic fibrosis altered defensin levels affect mucus-associated bacterial load. The interplay between DEFb-1 and the CFTR protein highlights its impact on surface clearance and infection susceptibility.