Abcam, ab144396, GSK-J1, H3K27 histone demethylase inhibitor

Size: 10mg / 50mg
MW 389.4 Da, Purity >99%. Potent and selective H3K27 histone demethylase inhibitor (IC 50 = 60 nM, JMJD3). Inhibits UTX. Some activity for the H3K4me3/2/1 demethylases Jarid1b and Jarid1c (IC 50 values are 950 nM and 1.76 μM, respectively). No significant inhibitory activity against 100 protein kinases at a concentration of 30 μM. Anti-inflammatory effects.
Key facts
CAS number:1373422-53-7,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:389.4 Da,
Molecular formula:C22H23N5O2,
PubChem:56963315,
Nature:Synthetic,
Biochemical name:3-[[2-Pyridin-2-Yl-6-(1,2,4,5-Tetrahydro-3-Benzazepin-3-Yl)pyrimidin-4-Yl]amino]propanoic Acid,
Biological description:Potent and selective H3K27 histone demethylase inhibitor (IC50 = 60 nM, JMJD3). Inhibits UTX. Some activity for the H3K4me3/2/1 demethylases Jarid1b and Jarid1c (IC50 values are 950 nM and 1.76 μM, respectively). No significant inhibitory activity against 100 protein kinases at a concentration of 30 μM. Anti-inflammatory effects.,
Canonical smiles:C1CN(CCC2=CC=CC=C21)C3=NC(=NC(=C3)NCCC(=O)O)C4=CC=CC=N4,
InChi:InChI=1S/C22H23N5O2/c28-21(29)8-12-24-19-15-20(26-22(25-19)18-7-3-4-11-23-18)27-13-9-16-5-1-2-6-17(16)10-14-27/h1-7,11,15H,8-10,12-14H2,(H,28,29)(H,24,25,26),
InChiKey:AVZCPICCWKMZDT-UHFFFAOYSA-N,
IUPAC Name:3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months