Abcam, ab144534, Chaetocin, histone lysine methyltransferase inhibitor

Size: 200µg
MW 696.8 Da, Purity >98%. Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo . It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.
Key facts
CAS number:28097-03-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:696.8 Da,
Molecular formula:C30H28N6O6S4,
PubChem:161591,
Nature:Synthetic,
Solubility:Soluble in DMSO to 10 mM,
Biochemical name:Chaetocin from Chaetomium minutum,
Biological description:Specific inhibitor of the lysine-specific methyltransferase SU (VAR)3-9 both in vitro and in vivo. It displays potent antimyeloma activity in IL-6-dependent myeloma cell lines. Its antimyeloma activity appears to be due to induction of oxidative stress and consequent apoptosis.,
Canonical smiles:CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C,
InChi:InChI=1S/C30H28N6O6S4/c1-33-21(39)27-11-25(15-7-3-5-9-17(15)31-19(25)35(27)23(41)29(33,13-37)45-43-27)26-12-28-22(40)34(2)30(14-38,46-44-28)24(42)36(28)20(26)32-18-10-6-4-8-16(18)26/h3-10,19-20,31-32,37-38H,11-14H2,1-2H3,
InChiKey:PZPPOCZWRGNKIR-UHFFFAOYSA-N,
IUPAC Name:14-(hydroxymethyl)-3-[14-(hydroxymethyl)-18-methyl-13,17-dioxo-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-trien-3-yl]-18-methyl-15,16-dithia-10,12,18-triazapentacyclo[12.2.2.01,12.03,11.04,9]octadeca-4,6,8-triene-13,17-dione

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months