Abcam, ab144572, BIX 02188, MEK5 inhibitor

Size: 10mg / 50mg
MW 412.5 Da, Purity >98%. Potent, selective MEK5 inhibitor (IC 50 = 4.3 nM). Blocks phosphorlyation of ERK5, without affecting phosphorylation of ERK1/2. Induces apoptosis in FLT3-ITD cells. Centrally active in vivo. .
Key facts
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:412.5 Da,
Molecular formula:C25H24N4O2,
PubChem:66524294,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:CID 66524294,
Biological description:Potent, selective MEK5 inhibitor (IC50 = 4.3 nM). Blocks phosphorlyation of ERK5, without affecting phosphorylation of ERK1/2. Induces apoptosis in FLT3-ITD cells. Centrally active in vivo.,
Canonical smiles:CN(C)CC1=CC(=CC=C1)NC(=C2C3=C(C=C(C=C3)C(=O)N)NC2=O)C4=CC=CC=C4,
Isomeric smiles:CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N)NC2=O)/C4=CC=CC=C4,
InChi:InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22-,
InChiKey:FSZPIAXLCCQFCM-FCQUAONHSA-N,
IUPAC Name:(3Z)-3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxamide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months