Abcam, ab145050, NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist

Size: 10mg / 50mg
MW 445.4 Da, Purity >99%. Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects *in vivo.* Orally active.
Key facts
CAS number:324523-20-8,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:445.4 Da,
Molecular formula:C24H26Cl2N2O2,
PubChem:9868131,
Nature:Synthetic,
Solubility:Soluble in ethanol to 10 mMSoluble in DMSO to 100 mM,
Biochemical name:NPS 2143 hydrochloride,
Biological description:Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects *in vivo.* Orally active.,
Canonical smiles:CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O.Cl,
Isomeric smiles:CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O.Cl,
InChi:InChI=1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1,
InChiKey:ZEBNDUQLNGYBNL-VEIFNGETSA-N,
IUPAC Name:2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile;hydrochloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months