Abcam, ab145144, Ceefourin™ 1, MRP4 inhibitor

Size: 1mg / 5mg
MW 294.4 Da, Purity >99%. Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 1.5 µM). Blocked transport of MRP4 substrates 6-Mercaptopurine, SN 38, cAMP, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 2 (ab145145).
Key facts
CAS number:315702-40-0,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:294.4 Da,
Molecular formula:C11H10N4S3,
PubChem:704306,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:5-[(1,3-benzothiazol-2-ylsulfanyl)methyl]-4-methyl-4H-1,2,4-triazole-3-thiol,
Biological description:Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 1.5 µM). Blocked transport of MRP4 substrates 6-Mercaptopurine, SN 38, cAMP, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 2 (ab145145).,
Canonical smiles:CN1C(=NNC1=S)CSC2=NC3=CC=CC=C3S2,
InChi:InChI=1S/C11H10N4S3/c1-15-9(13-14-10(15)16)6-17-11-12-7-4-2-3-5-8(7)18-11/h2-5H,6H2,1H3,(H,14,16),
InChiKey:KVNBVHCJAUXKPJ-UHFFFAOYSA-N,
IUPAC Name:3-(1,3-benzothiazol-2-ylsulfanylmethyl)-4-methyl-1H-1,2,4-triazole-5-thione

Product details:
Sold under exclusive licence from Children's Cancer Institute. Ceefourin™ is a trademark of Children's Cancer Institute.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MRP4 protein also known as Multidrug Resistance Protein 4 or ABCC4 is an ATP-binding cassette transporter with a mass of approximately 150 kDa. This protein is expressed in various tissues including the liver kidney and brain. It plays a mechanical role by transporting organic anions drugs and other xenobiotic compounds across cellular membranes. MRP4 is part of the wider ATP-binding cassette (ABC) transporter family which actively pumps substrates against concentration gradients using ATP hydrolysis.
Biological function summary
MRP4 impacts processes like pharmacokinetics and drug metabolism. The protein contributes to the efflux of endogenous substrates and medication from cells affecting their absorption and excretion. MRP4 also functions as part of a larger transporter complex working with other similar proteins to manage cellular detoxification systems. The MRP4 transporter maintains cellular homeostasis by removing harmful substances supporting cellular defense mechanisms against xenobiotic and endogenous compounds.
Pathways
MRP4 integrates into cellular processes such as prostaglandin and cyclic nucleotide signaling pathways. These pathways are important in regulating inflammatory responses and cardiovascular functions. MRP4 interacts with other proteins including MRP1 and MRP5 which facilitate the movement of similar substrates providing flexibility and redundancy within cellular transport systems. This involvement enables MRP4 to modulate biological effects via alteration in prostaglandin levels.
MRP4 connects to conditions such as cancer and viral infections. Elevated expression of MRP4 can lead to drug resistance in cancer therapy complicating treatment strategies. In viral infections MRP4 modulates the availability of nucleoside analogs used in antiviral therapies. The protein's role aligns with other transporters like P-glycoprotein showcasing its involvement in the multidrug resistance phenotype. Consequently understanding MRP4's function can aid in the development of new therapeutic approaches targeting these disorders.