Abcam, ab145145, Ceefourin™ 2, MRP4 inhibitor

Size: 1mg / 5mg
MW 355.7 Da, Purity >98%. Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).
Key facts
CAS number:348148-51-6,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:355.7 Da,
Molecular formula:C15H9ClF3N3O2,
PubChem:1366977,
Nature:Synthetic,
Solubility:Soluble in DMSO to 25 mM,
Biochemical name:3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid,
Biological description:Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 *in vitro*. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).,
Canonical smiles:CC1=CC=C(C=C1)C2=NC3=C(C(=NN3C(=C2)C(F)(F)F)C(=O)O)Cl,
InChi:InChI=1S/C15H9ClF3N3O2/c1-7-2-4-8(5-3-7)9-6-10(15(17,18)19)22-13(20-9)11(16)12(21-22)14(23)24/h2-6H,1H3,(H,23,24),
InChiKey:ZGYIZPUVZOKRHH-UHFFFAOYSA-N,
IUPAC Name:3-chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Product details:
Sold under exclusive licence from Children's Cancer Institute. Ceefourin™ is a trademark of Children's Cancer Institute.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months