Abcam, ab146140, PX 12, Thioredoxin-1 inhibitor

Size: 5mg / 25mg
MW 188.3 Da, Purity >98%. Irreversible, competitive Thioredoxin-1 inhibitor (K i = 30.8 μM). Attenuates HIF-1α, VEGF and iNOS expression (IC 50 values are 7.2, 10.4 and 18.1 μM, respectively). Inhibits tubulin and decreases tumor blood vessel density. Shows antitumor effects in vivo. .
Key facts
CAS number:141400-58-0,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:188.3 Da,
Molecular formula:C7H12N2S2,
PubChem:219104,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mM,
Biochemical name:2-(Sec-butyldisulfanyl)-1h-imidazole,
Biological description:Irreversible, competitive Thioredoxin-1 inhibitor (Ki = 30.8 μM). Attenuates HIF-1α, VEGF and iNOS expression (IC50 values are 7.2, 10.4 and 18.1 μM, respectively). Inhibits tubulin and decreases tumor blood vessel density. Shows antitumor effects in vivo.,
Canonical smiles:CCC(C)SSC1=NC=CN1,
InChi:InChI=1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9),
InChiKey:BPBPYQWMFCTCNG-UHFFFAOYSA-N,
IUPAC Name:2-(butan-2-yldisulfanyl)-1H-imidazole

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2217 PX 12. 2217-25 is the same size as the 25 mg size of ab146140.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months