Abcam, ab147491, Domperidone (DMSO Solution)

Size: 5mg
MW 425.9 Da. Peripheral D 2 -like receptor antagonist. Does not readily cross the blood-brain barrier, and displays gastrokinetic and antiemetic properties.
Key facts
CAS number:57808-66-9,
Form:LiquidSee storage information,
Molecular weight:425.9 Da,
Molecular formula:C22H24ClN5O2,
PubChem:3151,
Nature:Synthetic,
Biochemical name:Domperidone,
Biological description:Peripheral D2-like receptor antagonist. Does not readily cross the blood-brain barrier, and displays gastrokinetic and antiemetic properties.,
Canonical smiles:C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O,
InChi:InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30),
InChiKey:FGXWKSZFVQUSTL-UHFFFAOYSA-N,
IUPAC Name:6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C-Jun is a protein that functions as a transcription factor and is a part of the Activator Protein 1 (AP-1) complex. It is also known as Jun proto-oncogene. This protein is involved in regulating gene expression related to cell proliferation differentiation and apoptosis. The molecular mass of c-Jun is about 39 kDa. It is widely expressed in various tissues particularly found in the brain liver and spleen where it influences cellular responses to growth signals and stress.
Biological function summary
C-Jun plays an important role in cell cycle control and stress response mechanisms. It dimerizes with other proteins like c-Fos to form the AP-1 complex which binds to DNA and regulates transcription. This protein is involved in various cellular processes including neuronal activity and immune response influencing the expression of genes involved in cellular survival and death. c-Jun activation is typically mediated through signaling cascades such as the MAPK pathway.
Pathways
C-Jun is central to signaling pathways like JNK and ERK which are important for transmitting signals from membrane receptors to the cell nucleus. It interacts with proteins such as c-Fos and various kinases involved in these pathways to mediate cellular responses to extracellular stimuli. Within these signaling cascades c-Jun plays a pivotal role in translating external signals into specific gene expression patterns which are imperative for cellular adaptation and response.
C-Jun is associated with a variety of pathological conditions including cancer and neurodegenerative diseases. Overexpression or dysregulation of c-Jun has been implicated in the development of tumors as it may lead to abnormal cell proliferation. In neurodegenerative disorders such as Alzheimer's disease altered c-Jun activity can contribute to neuronal dysfunction and apoptosis. Researchers study its interactions with proteins like TDP1 and other AP-1 components to better understand its role in these diseases.