Abcam, ab150346, Anti-Leu Enkephalin antibody [NOC1]

Size: 100µL
Mouse Monoclonal Enkephalin antibody. Suitable for ICC, IHC-P, RIA, IHC-Fr and reacts with Mouse, Rat, Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human PENK conjugated to Bovine Serum Albumin.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:NOC1,
Isotype:IgG1,
Carrier free:No,
Reacts with:Rat, Human, Mouse,
Applications:IHC-Fr, ICC, IHC-P, RIASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PENK conjugated to Bovine Serum Albumin. The exact immunogen used to generate this antibody is proprietary information.P01210,
Specificity:This antibody does not distinguish between Met-enkephalin and Leu-enkephalin by radioimmunoassay or by immunocytochemistry.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Purification notes-ab150346 is in a protein-free culture medium., Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Leu-enkephalin also known as leucine-enkephalin is a pentapeptide with the sequence Tyr-Gly-Gly-Phe-Leu. This enkephalin with a molecular mass of approximately 555.6 Da primarily expresses in the central nervous system where it acts as a neurotransmitter and neuromodulator. It binds to the delta opioid receptors mediating various physiological functions. Leu-enkephalin and its structural variant Met-enkephalin are notable for their role in modulating pain perception and producing analgesic effects.
Biological function summary
Enkephalins are endogenous peptides involved in pain regulation and stress responses. These peptides are important in the body’s ability to cope with stressors and reduce pain signals. Enkephalins including Leu-enkephalin inhibit neurotransmitter release by binding to specific opioid receptors found throughout the nervous system. They are not part of a larger protein complex but are a vital component in neurotransmission processes.
Pathways
Enkephalins play a significant role in the endogenous opioid pathway interacting closely with delta opioid receptors. This interaction affects the brain's reward and pain pathways. The endogenous opioid pathway involves other opioid peptides such as beta-endorphins and dynorphins which Leu-enkephalin functions alongside. These pathways are significant in managing emotional states related to reward and pain modulation.
Leu-enkephalin is linked to conditions such as chronic pain and opioid addiction. Dysregulation of enkephalin production or receptor function may contribute to these disorders. The delta opioid receptor which Leu-enkephalin binds is often a target in research seeking to develop safer analgesics by minimizing addiction potential. Understanding these interactions helps in developing therapeutic strategies that may mitigate adverse effects associated with pain management and addiction therapies.