Abcam, ab150390, Anti-HSPB7 antibody [EPR10106(B)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal HSPB7 antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse, Rat samples. Cited in 15 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10106(B),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.14% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HSPB7 also known as Heat Shock Protein Beta-7 or cvHSP is a small heat shock protein implicated in stress response mechanisms. It has a molecular mass of approximately 19 kDa. Researchers have identified its expression in cardiac and skeletal muscles as well as in adipose tissue. This protein has a protective role in preventing protein aggregation under stress conditions indicating its significance in cellular homeostasis.
Biological function summary
HSPB7 interacts with cellular components to maintain proteostasis. It participates in the formation of protein complexes binding to other small heat shock proteins to stabilize denatured proteins. This interaction serves to ensure proper protein folding and prevent aggregation within the cells. Such mechanisms highlight HSPB7’s function in maintaining muscle structure and function by assisting in protein maintenance.
Pathways
HSPB7 participates in the regulation of muscle function and stress response pathways. It connects to the MAPK signaling pathway which influences cell survival and apoptosis. Additionally HSPB7 interacts with related proteins such as HSPB2 playing a role in muscle maintenance and response to mechanical stress. These pathways highlight HSPB7’s involvement in cellular adaptation to stress stimuli.
HSPB7 has links to cardiomyopathy and muscular dystrophy. Mutations in HSPB7 correlate with an increased risk of developing familial dilated cardiomyopathy implicating it in cardiac dysfunctions. Additionally its association with proteins like HSPB1 suggests a potential role in muscle degenerative diseases. Understanding HSPB7’s role in these conditions could provide insights for therapeutic interventions aimed at mitigating muscle and heart diseases.