Abcam, ab150404, Anti-Zic2 antibody [EPR7790]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ZIC2 antibody. Suitable for ICC/IF, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 17 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7790,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody detects a 70kDa extra band in some cell lines.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Zic2 also called Zinc finger protein of cerebellum 2 represents a transcription factor notable for its role in the regulation of gene expression. Mechanically Zic2 binds to DNA sequences via its zinc finger domains facilitating transcriptional activation or repression depending on the context. This protein has an approximate molecular mass of 60 kDa and exhibits expression mainly in the developing central nervous system. Zic2 shows high levels of expression in postmitotic neurons and various embryonic tissues indicating its involvement in central neural developmental processes.
Biological function summary
Zic2 impacts the differentiation and proliferation of neural progenitor cells. Zic2 functions as part of a transcriptional regulatory complex collaborating with other partners to control genes necessary for neurodevelopment. Its activity supports the specification of neuronal identity and axonal pathfinding. Studies demonstrate its important role in guiding axons to their correct targets a function integral during the formation of neural circuits. Zic2-mediated transcriptional networks are essential for accurate neuronal patterning in the central nervous system.
Pathways
Several interactions revolving around Zic2 play essential roles. Zic2 is involved in the Sonic Hedgehog (Shh) signaling pathway where it contributes to the transcriptional response important for patterning activities. Within the Shh pathway Zic2 interacts with downstream components like Gli proteins which modulate target gene expression based on signal gradient. Additionally Zic2 participates in the Wnt signaling pathway where it influences cell fate determination and tissue polarity. Such pathways highlight its part in developmental processes and cellular differentiation.
Mutations or dysregulation of Zic2 often associate with congenital malformations such as holoprosencephaly and mirror movement disorder. These disorders arise from disrupted neural development reflecting Zic2's key roles in morphogenesis and patterning. Both conditions involve abnormal neurodevelopment where altered Zic2 interactions with proteins such as Gli3 result in impaired signaling cascades. Understanding these connections helps clarify Zic2's contribution to pathological states offering insights into potential therapeutic targets.