Abcam, ab150510, Anti-CRHR2 antibody

Size: 50µg
Rabbit Polyclonal CRHR2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CRHR2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CRHR2. The exact immunogen used to generate this antibody is proprietary information.Q13324,
Specificity:BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Corticotropin-releasing hormone receptor 2 (CRHR2) also known as CRF2 receptor is a protein encoded by the CRHR2 gene. Mechanically CRHR2 functions by binding to corticotropin-releasing hormone (CRH) and related peptides leading to activation of intracellular signaling pathways. This receptor is a member of the G protein-coupled receptor family and is approximately 47 kDa in mass. CRHR2 is expressed in diverse tissues prominently in the brain heart gastrointestinal tract and skeletal muscle.
Biological function summary
The receptor regulates stress-related and homeostatic functions. It plays a significant role in mediating the effects of CRH and urocortins on the central nervous system and peripheral tissues. The receptor contributes to managing anxiety cardiovascular function gastric motility and energy homeostasis. Although CRHR2 does not form a part of a larger complex it closely interacts with other neuropeptides and their receptors to maintain physiological balance.
Pathways
CRHR2 is integrated into important signaling networks like the hypothalamic-pituitary-adrenal (HPA) axis and the stress response pathway. In these pathways CRHR2 influences cortisol release and modulates stress responses. Related proteins include CRHR1 which also binds CRH facilitating modulation of adaptive responses to stress. Additionally CRHR2 interacts with intracellular proteins that regulate signal transduction cascades linked to mood regulation and anxiety management.
CRHR2 has associations with conditions like depression and cardiovascular diseases. Elevated or altered activity of CRHR2 can affect mood regulation pathways leading to an increased risk of depression. The receptor's role in cardiovascular regulation links it to heart diseases where altered signaling can impact heart rate and blood pressure. CRHR2 is associated with proteins such as CRH which can jointly influence the susceptibility to these disorders by modulating stress and cardiovascular responses.