Abcam, ab15053, Anti-PCYT2 antibody

Size: 50µg
Rabbit Polyclonal PCYT2 antibody. Suitable for ICC and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PCYT2 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.Q99447

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.02% Thimerosal (merthiolate)Constituents: 99% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PCYT2 also known as ethanolamine-phosphate cytidylyltransferase is an enzyme that plays a critical role in phospholipid metabolism. It has a molecular mass of approximately 41 kDa. PCYT2 is expressed in various tissues with high levels found in the liver and brain. The enzyme catalyzes the conversion of phosphoethanolamine and CTP to CDP-ethanolamine an important step in the CDP-ethanolamine pathway which synthesizes phosphatidylethanolamine.
Biological function summary
The function of PCYT2 centers around lipid metabolism and membrane biosynthesis. PCYT2 acts as an integral component of the CDP-ethanolamine pathway which is essential for the production of phosphatidylethanolamine a principal phospholipid in cell membranes. It works in conjunction with other enzymes to ensure the proper biosynthesis of phospholipids. Although its precise participation as part of a larger protein complex remains uncertain its enzymatic activity is significant for lipid homeostasis.
Pathways
The activity of PCYT2 mainly fits into the phosphatidylserine decarboxylation and CDP-ethanolamine pathways. The enzyme interacts with CDP-diacylglycerol and phosphatidylcholine playing a significant role in lipid assembly and remodeling of cellular membranes. It shares functional interactions within these pathways with other enzymes like CHPT1 which further converges toward the regulation of phosphatidylcholine and phosphatidylethanolamine synthesis.
Mutations in PCYT2 have been linked to neurodegenerative diseases and certain metabolic disorders. Its dysfunction can contribute to neurological symptoms due to its fundamental role in maintaining normal brain phospholipid levels. The protein's connections to disorders particularly concerning phospholipid imbalance include interactions with related enzymes like EPT1. Such connections underline how PCYT2 disruptions can impact phospholipid biosynthesis and potential disease outcomes.