Abcam, ab150653, Anti-HGS antibody [19-5]

Size: 50µg
Mouse Monoclonal HGS antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HGS.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:19-5,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human HGS.O14964,
Epitope:The epitope for ab150653 is located between the VHS and coiled-coil domain of HGS.,
Specificity:The antibody recognizes an epitope is located between the VHS and coiled-coil domain of the HRS protein.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Lyophilized protein G purified in PBS pH7.4, Storage buffer-pH: 7.2Constituents: 100% Phosphate Buffer, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HGS protein also known as hepatocyte growth factor-regulated tyrosine kinase substrate plays a significant role in cellular processes. It has a molecular mass of approximately 82 kDa. You will find HGS expressed broadly especially in epithelial tissues where it contributes to regulating various cellular mechanisms. Alternative names for HGS include HRS and HGS products which reflect its involvement in various signaling pathways and functions.
Biological function summary
The HGS acts as a central player in endosomal sorting and targeting processes. It forms a part of the ESCRT-0 complex important for the degradation of surface receptors as it directs ubiquitinated membrane proteins to lysosomes for degradation. HGS interacts with other proteins in the complex such as STAM (Signal transducing adaptor molecule). This role explains its importance in maintaining proper cellular signaling and balance.
Pathways
The HGS protein participates in the endocytosis and ubiquitin-proteasome pathways. HGS plays a critical role in the degradation of epidermal growth factor receptor (EGFR) by assisting its trafficking to lysosomes. This function ties it to cellular communication and signal transduction particularly related to growth signals. Within these pathways HGS closely interacts with proteins such as the hepatocyte growth factor (HGF) and c-Met playing a regulatory role in signal attenuation.
Aberrations in the HGS function link to cancer and neurodegenerative disorders. Dysregulation of the HGS-mediated pathways can lead to abnormal cell growth and cancer progression particularly in epithelial tissues. Additionally research indicates a connection between HGS dysfunction and Alzheimer's disease as it may influence amyloid-beta processing. Interactions with proteins like EGFR and c-Met suggest that alterations in the HGS activity could have significant implications for disease pathogenesis and progression.