Abcam, ab150761, Anti-DSCAML1 antibody [DS1-96]

Size: 200µg / 100µg
Mouse Monoclonal DSCAML1 antibody. Suitable for IHC-FoFr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Chicken DSCAML1 aa 750-1100.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:DS1-96,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:IHC-FoFrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Chicken DSCAML1 aa 750-1100. The exact immunogen used to generate this antibody is proprietary information.E1C8P7,
Specificity:A specific antibody against DscamL. The antibody recognizes the C-terminal of the chicken DscamL protein (aa 761 to 1072).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Lyophilized protein G purified in PBS pH7.4, Storage buffer-Constituents: 99% Water, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, +4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein DSCAML1 also known as Down syndrome cell adhesion molecule-like 1 plays a mechanical role in cell adhesion and signaling. This protein with a mass of approximately 220 kDa belongs to the immunoglobulin superfamily. DSCAML1 is expressed in various tissues most notably in the nervous system where it helps in the development of neural circuits. The target is known for its complex structure which allows it to mediate homophilic cell-cell interactions essential for neuronal positioning and axonal pathfinding.
Biological function summary
DSCAML1 is involved in neural patterning and synaptic connectivity. The protein contributes to neural migration processes during development ensuring proper brain morphogenesis. Research suggests that DSCAML1 forms part of a molecular complex that aids in axon guidance important for network formation within the brain. Together with other cell adhesion molecules DSCAML1 influences synapse formation and stability impacting neural networks' functional integrity.
Pathways
DSCAML1 participates in signaling pathways critical for nervous system development. It significantly influences axon guidance and synaptic signaling pathways. DSCAML1 interacts with other proteins like DSCAM and DCC (Deleted in Colorectal Cancer) which are known to play roles in cellular communication and neuronal growth processes. These interactions contribute to the proteins' collective ability to orchestrate developmental and functional aspects of the central nervous system.
DSCAML1 mutations have associations with neurodevelopmental disorders such as autism spectrum disorders and intellectual disabilities. Alterations in DSCAML1 functions may disrupt neural circuitry leading to these conditions. Proteins like DSCAM whose gene duplication or mutations often occur in Down syndrome share pathways or functions with DSCAML1 and disruptions in these interactions stand linked to altered neural development and related cognitive concerns.