Abcam, ab150788, Anti-PGT antibody

Size: 100µL
Rabbit Polyclonal PGT antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLCO2A1 aa 400-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLCO2A1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.Q92959

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Prostaglandin transporter often referred to as PGT or SLCO2A1 is an organic anion transporting polypeptide. This protein facilitates the uptake of prostaglandins such as PGE2 into cells. PGT is approximately 65 kDa in size. It is predominantly expressed in the lungs kidneys and placenta. The function of PGT is important for mediating cellular responses to prostaglandins which are lipid compounds involved in various physiological processes.
Biological function summary
PGT mediates the reuptake and clearance of prostaglandins influencing inflammation and other processes. It is part of the complex network that controls local prostaglandin levels within tissues. Besides regulating inflammatory responses it also impacts cellular signaling pathways that govern processes such as cell growth and apoptosis.
Pathways
PGT integrates into the prostaglandin signaling pathway. It plays a significant role in regulating the bioavailability of prostaglandins impacting both the prostaglandin-endoperoxide synthase (also known as cyclooxygenase) pathway and its related receptors. By controlling prostaglandin levels PGT indirectly affects proteins related to these pathways such as cyclooxygenases COX-1 and COX-2.
PGT's regulation of prostaglandin levels can influence conditions like inflammatory diseases and certain cancers. Its involvement in prostaglandin metabolism connects it with proteins like COX-2 which are prominently upregulated in inflammatory states and certain malignancies. Targeting PGT can help modulate these pathways for therapeutic interventions in diseases linked to abnormal prostaglandin levels.