Abcam, ab150906, Anti-UNC119-binding protein C5orf30 antibody

Size: 100µL
Rabbit Polyclonal UNC119-binding protein C5orf30 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MACIR aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MACIR aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q96GV9

Product details:
The antibody solution should be gently mixed before use.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UNC119-binding protein C5orf30 also known as C5orf30 is a protein with a known sequence mass of approximately 24 kDa. This protein mechanically interacts with UNC119 a protein involved in the trafficking of proteins to cilia and photoreceptor cells. C5orf30 shows broad expression in many tissues including immune cells and the central nervous system. The interaction with UNC119 suggests a role in processes related to intracellular transport and signaling.
Biological function summary
The function of C5orf30 involves modulating immune response and inflammation. While not a part of a large protein complex C5orf30 influences signal transduction pathways through its interaction with other signaling proteins. It links to the regulation of the immune system where it helps maintain balance and prevents overactivation which can lead to autoimmune issues. Its expression and activity indicate its role in immune regulation.
Pathways
The protein C5orf30 plays a part in the regulation of the JAK-STAT signaling pathway which is essential for immune function and cellular responses to cytokines. It influences the activity of proteins like STAT1 and STAT3 commonly involved in transcriptional regulation and inflammatory responses. Another pathway C5orf30 interacts with is the Wnt signaling pathway impacting cellular proliferation and differentiation. Through these pathways C5orf30 connects with other signaling proteins modulating processes critical for maintaining immune homeostasis.
C5orf30 has been linked to rheumatoid arthritis and inflammatory bowel disease. Both conditions involve dysregulation of the immune system where C5orf30 is believed to play a role in disease progression. The protein associates with other proteins like IL-6 and TNF-alpha which are key regulators of inflammation in these disorders. Understanding C5orf30's interactions may help in developing therapeutic strategies for these diseases.