Abcam, ab150921, Anti-PNMA5 antibody

Size: 100µL
Rabbit Polyclonal PNMA5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PNMA5 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PNMA5 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96PV4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PNMA5 also known as Paraneoplastic Ma antigen family member 5 is a protein with a molecular mass of approximately 55 kDa. This protein localizes mainly in neuronal tissues and researchers have detected it particularly in brain regions. PNMA5 exhibits a typical structure shared with other members of the PNMA family which suggests a conserved function across this group of proteins. This structural resemblance indicates that PNMA5 likely plays a role in cellular processes important for neuronal activity.
Biological function summary
PNMA5 contributes to cellular mechanisms related to neuronal function and survival. While it is not known to form part of a defined protein complex PNMA5 interacts with other neuronal proteins to facilitate processes essential for maintaining neuronal integrity and health. The protein's function becomes valuable in understanding processes underlying cell survival and response to cellular stress.
Pathways
PNMA5 shows relevance within the neuronal signaling and cellular stress response pathways. These pathways ensure that neurons operate efficiently and adaptively especially under stress conditions. In relation to these pathways the BAX protein is an important associated element as both play roles in the regulation of apoptosis in neurons. The interaction with BAX highlights the function of PNMA5 in mediating cellular responses during critical periods of cellular stress.
PNMA5 has been associated with certain neurological conditions including paraneoplastic syndromes which involve immune-mediated neuronal damage. The dysfunction of PNMA5 in connection with other PNMA family members like PNMA1 may contribute to the pathogenesis of these disorders. Understanding the involvement of PNMA5 in these diseases might reveal new insights into their underlying mechanisms and potential therapeutic targets.