Abcam, ab150986, Anti-C10orf11 antibody

Size: 100µL
Rabbit Polyclonal C10orf11 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LRMDA aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LRMDA aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H2I8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C10orf11 also known as Chromosome 10 open reading frame 11 is a protein-coding gene with a mass of approximately 55 kDa. Researchers have observed its expression in various tissues most notably within the skin and melanocytes. While the exact mechanical function of C10orf11 remains partially understood studies indicate that it likely participates in cellular processes by interacting with other proteins.
Biological function summary
The gene plays an important role in pigmentation. C10orf11 appears to be involved in the regulation of melanin production making it important for skin color and other pigmentation processes. It is not known to be part of a specific protein complex but its interactions suggest it influences the activity of melanogenesis-related genes.
Pathways
C10orf11 primarily connects to the melanogenesis pathway. This pathway is integral for producing melanin and C10orf11 might regulate or interact with other proteins involved in melanin synthesis such as TYR (tyrosinase). The gene's involvement implies a regulatory function that impacts the production and distribution of pigment within cells.
C10orf11 has been associated with pigmentation disorders such as Waardenburg Syndrome. This syndrome involves abnormal pigmentation and hearing loss where C10orf11 might interact with proteins like MITF an important transcription factor in melanocyte function. Understanding these interactions might provide insights into the mechanisms underlying related conditions.