Abcam, ab151015, Anti-MOCOS/MCS antibody

Size: 100µL
Rabbit Polyclonal MOCOS/MCS antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
The antibody solution should be gently mixed before use.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Molybdenum cofactor sulfurase (MOCOS) also known as MCS is an important enzyme in sulfur transfer for the activation of molybdenum cofactor. MOCOS weighs approximately 88 kDa and is found in a variety of tissues including liver and kidney. It plays a critical role in the biochemical process of activating the molybdenum cofactor which is essential for the proper function of certain enzymes.
Biological function summary
MOCOS contributes significantly to a sulfurase complex that includes other enzymes responsible for molybdenum cofactor biosynthesis and activation. It specifically introduces sulfur into the cofactor which is important for the functionality of molybdenum-dependent enzymes like xanthine dehydrogenase and aldehyde oxidase. MOCOS's activity impacts not just individual enzyme functions but whole biochemical pathways governed by these enzymes.
Pathways
MOCOS's biological function integrates into the purine degradation pathway and the aldehyde detoxification pathway. The enzyme works collaboratively with xanthine dehydrogenase in purine metabolism enabling the conversion of hypoxanthine to xanthine and subsequently to uric acid. In the aldehyde detoxification pathway MOCOS-associated enzymes such as aldehyde oxidase contribute to the breakdown of aromatic aldehydes and heterocyclic compounds playing a role in metabolizing pharmaceuticals and toxins.
MOCOS deficiencies relate to xanthinuria Type II characterized by an excessive accumulation of xanthine due to impaired xanthine dehydrogenase activity. Individuals with dysfunctional MOCOS can experience xanthine oxidation defects leading to potential renal complications due to stone formation. This relates closely to aldehyde oxidase whose reduced activity might impact drug metabolism and increase susceptibility to certain aldehyde-induced cellular damages.