Abcam, ab151077, Anti-TMEM121 antibody

Size: 100µL
Rabbit Polyclonal TMEM121 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM121 aa 200-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM121 aa 200-300. The exact immunogen used to generate this antibody is proprietary information.Q9BTD3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM121 also known as Transmembrane Protein 121 is a protein that remains not fully characterized. It is estimated to have a molecular mass of approximately 18 kDa. This protein is expressed mainly in the brain according to available gene expression data. Although specific cellular functions of TMEM121 are yet to be clearly defined it is known to belong to the family of transmembrane proteins suggesting its role in cellular communication or transport across the cell membrane.
Biological function summary
TMEM121 may be involved in processes like signaling and maintaining cellular architecture given its nature as a transmembrane protein. While current research does not conclusively identify it as part of a particular complex its transmembrane characteristic points to potential interactions with other cytosolic or membrane proteins. These interactions could influence various intracellular pathways and contribute to cell function regulation.
Pathways
TMEM121 connects to neural signaling pathways and might play a role in the brain's neurodevelopmental processes. Researchers have proposed connections with proteins involved in synaptic function pointing towards its potential involvement in neurotransmission. The exact pathways remain under investigation but evidence suggests TMEM121's association with neural activity and possibly neurotransmitter regulation.
TMEM121 associates with neurological conditions such as epilepsy and neurodevelopmental disorders due to its expression pattern in the brain. Limited studies hint at connections with proteins like GABA receptors although this relationship requires further detailed exploration to fully comprehend TMEM121's clinical implications. Understanding TMEM121's role in these conditions may provide insights into their pathogenesis and potential therapeutic approaches.