Abcam, ab151089, Anti-LYRM7 antibody

Size: 100µL
Rabbit Polyclonal LYRM7 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LYRM7 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LYRM7 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q5U5X0

Product details:
The antibody solution should be gently mixed before use.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LYRM7 also known as LYR motif-containing protein 7 has a mechanical role in mitochondrial function. This protein has a mass of approximately 13 kDa and is expressed mainly in the mitochondria of cells. It interacts closely with components of the mitochondrial complex making it integral to mitochondrial activity. Researchers have identified alternative names like BNF1 and MET7 for LYRM7 highlighting its diverse functions in different contexts.
Biological function summary
LYRM7 incorporates into the mitochondrial complex I an important component for cellular respiration. The protein contributes to the assembly of the mitochondrial complex ensuring proper cellular energy production. As part of the LYRM family of proteins LYRM7 facilitates interactions with NADH:ubiquinone oxidoreductase enhancing the efficiency of electron transport within mitochondria. This role associates LYRM7 with maintaining energy balance essential for normal cellular operations.
Pathways
LYRM7 plays a role in the mitochondrial electron transport chain and the oxidative phosphorylation pathway. LYRM7 is essential for the biogenesis of mitochondrial complex I working closely with other proteins like NDUFS2 which is a core complex I subunit. LYRM7’s function in these pathways ensures efficient electron transport and ATP production linking it to energy metabolism processes necessary for cellular and organ function.
Researchers have linked LYRM7 to mitochondrial complex I deficiency and Leigh syndrome. Patients with deficiencies in LYRM7 or related proteins like NDUFS2 experience disruptions in cellular respiration leading to severe metabolic disorders. Leigh syndrome a neurodegenerative disorder often arises from defects in mitochondrial energy production pathways with LYRM7 having a significant connection due to its role within the mitochondrial complex. Understanding LYRM7 and related proteins can provide insights into potential therapeutic targets for these diseases.