Abcam, ab151110, Anti-SBF2 antibody

Size: 100µL
Rabbit Polyclonal SBF2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SBF2 aa 1650-1750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SBF2 aa 1650-1750. The exact immunogen used to generate this antibody is proprietary information.Q86WG5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SBF2 also known as SET binding factor 2 or pseudophosphatase MTMR13 is a protein with a molecular weight of approximately 150 kDa. It functions as a pseudophosphatase which means it lacks catalytic activity typically seen in phosphatases but can still play a regulatory role. SBF2 shows strong expression in nervous tissue particularly in Schwann cells which are essential for peripheral nerve function. The protein contains a coiled-coil domain that may facilitate interactions with other proteins or cellular components.
Biological function summary
SBF2 participates in cellular processes linked to endocytosis the pathway that internalizes cell surface receptors and other molecules. It serves as part of a complex with active phosphatases like MTMR2 modulating their action and localization in the cell. Through these interactions SBF2 exerts influence over cellular homeostasis and membrane trafficking although the exact mechanisms are not fully understood. Despite its lack of enzymatic function it remains significant in organizing cellular responses that demand rapid adaptation.
Pathways
SBF2 contributes to the phosphatidylinositol signaling pathways affecting how cells perceive and react to external signals. In this manner it assists in the regulation of protein interactions for signal transduction. Together with MTMR2 SBF2 influences phosphatidylinositol 3-phosphate levels and modulates trafficking of endosomal proteins. It carries a role in directing cellular components and maintaining the clarity of signaling messages that depend on precise molecular feedback.
Mutations or dysregulation of SBF2 directly correlate with Charcot-Marie-Tooth disease type 4B a hereditary neuropathy characterized by demyelination. The condition affects peripheral nerves and connects SBF2 to dysfunction in myelin sheath maintenance. During these pathological states SBF2 often shows altered interactions with MTMR2 leading to disrupted myelin homeostasis. Understanding the role of SBF2 in these contexts paves a path to potential therapeutic strategies targeting neuropathic conditions involving impaired cellular signaling and protein trafficking.