Abcam, ab151304, Anti-MAEA antibody

Size: 100µL
Rabbit Polyclonal MAEA antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MAEA aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MAEA aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q7L5Y9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAEA also known as Macrophage Erythroblast Attacher is a protein with a mass of approximately 42 kDa. This protein functions mechanically by anchoring mature erythroblasts to macrophages in the erythroblastic islands of the bone marrow. You can find MAEA expression in hematopoietic organs such as the spleen bone marrow and lymph nodes. Its expression is not limited to these sites since several tissues exhibit lower levels of expression indicating a broader biological role.
Biological function summary
MAEA plays a significant role in hematopoiesis by facilitating communication between macrophages and erythroblasts. It forms part of a protein complex that ensures the stability and viability of developing erythrocytes. This protein interaction is critical for the normal maturation of red blood cells helping to maintain the balance and production of these cells under varying physiological conditions.
Pathways
MAEA participates in the erythrophagocytosis and erythroblast enucleation processes. MAEA contributes to the interaction with proteins such as ICAM-4 and VLA-4 which are important in these pathways. Through these interactions MAEA is instrumental in effectively mediating red blood cell clearance and differentiation ensuring the proper function of erythroblastic islands within the bone marrow niche.
MAEA links to pathologies such as anemia and myeloproliferative disorders. Altered MAEA expression or function can disturb normal erythropoiesis leading to ineffective red blood cell production and anemia. Additionally its interaction with proteins like ICAM-4 can affect disease progression and severity. Researchers continue to study these connections to understand MAEA’s role in hematological disorders better.