Abcam, ab151320, Anti-TRIOBP antibody - C-terminal

Size: 100µL
Rabbit Polyclonal TRIOBP antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Rat samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TRIOBP aa 1800-2100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TRIOBP aa 1800-2100. The exact immunogen used to generate this antibody is proprietary information.Q9H2D6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TRIOBP protein also known as Trio-Binding Protein has a molecular mass of approximately 75 kDa though it may vary depending on the isoform. It localizes in various tissues with strong expression in the brain suggesting a role in neural processes. TRIOBP interacts with the actin cytoskeleton mainly influencing cell shape and movement. It is known for binding to Trio a guanine nucleotide exchange factor involved in actin rearrangement which highlights its importance in maintaining structural integrity at the cellular level.
Biological function summary
This protein influences cellular dynamics by maintaining cytoskeletal architecture. TRIOBP can exist in several isoforms implicated in different cellular processes. It interacts with signaling complexes typically playing roles in neuronal development and synaptic functioning. In the context of cellular networks TRIOBP's involvement in communication pathways between cells supports its significance in maintaining efficient cellular communication.
Pathways
TRIOBP integrates into regulatory systems impacting neuronal signaling and actin cytoskeleton reorganization. The protein operates within pathways including the Rho GTPase signaling where it connects with proteins like Filamin A to mediate cytoskeletal alterations. It is also associated with pathways influencing neuronal growth working alongside DLG family proteins pivotal in synaptic signaling and plasticity.
Mutations or modifications in TRIOBP link to certain health conditions. It associates notably with schizophrenia where altered expression impacts neural connectivity. The protein also bears relevance to hearing loss interacting closely with DFNB28 gene products that affect inner ear hair cell function. Both conditions illustrate the protein's influence on nervous system integrity and sensory processing.