Abcam, ab151560, Anti-CARD6 antibody [EPR9718]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CARD6 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9718,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CARD6 also known as Caspase Recruitment Domain-Containing Protein 6 is a protein that weighs approximately 104 kDa. The protein is identified for its involvement in the immune response and connects with microtubules in the cell. It is expressed in various tissues including the heart brain and skeletal muscles. CARD6 contains a CARD (Caspase Activation and Recruitment Domain) enabling it to interact with other proteins containing similar domains.
Biological function summary
CARD6 influences immune system regulation playing a role in apoptosis and inflammation. It does not form a complex with other proteins but instead interacts directly with several proteins through its CARD domain. Notably CARD6 modulates the functions of NF-kB a transcription factor important for immune response regulation and cellular stress responses.
Pathways
CARD6 participates in the NF-kB signaling pathway and the interferon regulatory pathway. These pathways are essential for mediating immune responses and controlling inflammation within the body. CARD6 shows interaction with proteins like RIP2 and TRAF6 within these pathways which further affect the NF-kB signaling cascade.
CARD6 has been linked to Crohn's disease and certain cancers. Abnormalities in its function or expression can lead to dysregulated NF-kB activity contributing to these conditions. CARD6 interacts with proteins such as RIP2 in autoimmune disorders like Crohn's disease and its altered signaling pathway connections can play a role in cancer progression by affecting cell survival and proliferation mechanisms.