Abcam, ab151574, Anti-SH3KBP1 antibody [EPR7881(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SH3KBP1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR7881(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SH3 domain-containing kinase-binding protein 1 (SH3KBP1) also known as Cin85 is a multifunctional adapter protein involved in signal transduction pathways. It has a molecular mass of approximately 85 kDa. SH3KBP1 is expressed in a variety of tissues including the brain heart and lungs reflecting its diverse roles in cellular processes. This protein contains multiple SH3 domains that facilitate the binding with other proteins making SH3KBP1 an important modulator of protein-protein interactions.
Biological function summary
SH3KBP1 plays a role in cellular signaling and endocytosis. It forms part of a complex that participates in the regulation of membrane trafficking where it helps in internalization and down-regulation of receptor tyrosine kinases. SH3KBP1 interacts with other signaling molecules allowing it to coordinate the spatial and temporal dynamics of signaling pathways. This protein’s involvement in endocytic pathways highlights its significance in regulating cellular responses to external stimuli.
Pathways
SH3KBP1 is an integral part of the epidermal growth factor receptor (EGFR) signaling and the B-cell receptor (BCR) signaling pathways. In the EGFR pathway it facilitates receptor internalization affecting processes such as proliferation and survival. SH3KBP1 interacts with proteins like c-Cbl and Grb2 which are key players in receptor endocytosis and signal transduction. Through these interactions it modulates signal cascades that influence numerous cellular outcomes.
SH3KBP1 is implicated in cancer and autoimmune diseases. Its role in EGFR signaling connects it to cancer progression as dysregulation of this pathway can lead to uncontrolled cell growth. In autoimmune diseases SH3KBP1's interaction with BCR signaling components including CD19 and Syk can affect immune cell function and lead to pathological immune responses. Understanding the role of SH3KBP1 in these contexts can inform therapeutic strategies targeting its pathway involvement.