Abcam, ab151601, Anti-RNF13 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal RNF13 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RNF13 aa 300 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RNF13 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O43567

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 10% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RNF13 also known as RING finger protein 13 is a protein encoded by the RNF13 gene. It has a molecular mass of approximately 30 kDa. RNF13 is an E3 ubiquitin ligase a type of enzyme that mediates the transfer of ubiquitin from an E2 enzyme to a substrate protein tagging it for degradation by the proteasome. This protein contains a RING finger domain which is essential for its ligase activity. RNF13 is mainly expressed in the brain liver and kidney suggesting its involvement in varied cellular functions across these tissues.
Biological function summary
RNF13 plays a role in modulating protein turnover by tagging specific proteins for degradation thereby maintaining cellular homeostasis. It is part of the ubiquitin-proteasome system (UPS) a complex that regulates protein degradation and recycling within cells. Through its E3 ligase activity RNF13 affects processes like cell signaling cell cycle and responses to stress. In addition to the UPS RNF13 interacts with other proteins including those involved in membrane trafficking influencing how cells communicate and transport molecules internally.
Pathways
RNF13 is significantly involved in the endoplasmic reticulum-associated degradation (ERAD) pathway which removes misfolded or damaged proteins from the ER. It also participates in the Wnt signaling pathway a critical regulator of cell development and differentiation. In the context of the Wnt pathway RNF13 associates with proteins such as β-catenin influencing cell fate decisions. By connecting to these pathways RNF13 helps ensure proper cell growth and division acting as a molecular balance in cellular environments.
RNF13's dysregulation links to neurodegenerative diseases and certain cancers. In neurodegenerative conditions abnormal RNF13 function can affect protein clearance leading to aggregation that harms neurons as seen in Alzheimer's disease. Furthermore its role in cancer emerges through its involvement in pathways associated with cell proliferation; disruptions in its normal activity can lead to malignant transformations. In these disorders RNF13 can interact with proteins like p53 which is important for tumor suppression highlighting its importance in disease management and therapy development.