Abcam, ab151708, Anti-PFDN1 antibody [EPR8547]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PFDN1 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR8547,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PFDN1 protein also known as prefoldin subunit 1 functions as part of the chaperone pathway in protein folding. It helps in the stabilization of nascent polypeptides facilitating their correct folding into functional structures. The molecular mass of PFDN1 is approximately 15 kDa. Expression of PFDN1 occurs in various tissues which include both highly proliferative and differentiated cells. The protein has a wider tissue distribution suggesting its fundamental role in several cellular processes.
Biological function summary
The prefoldin complex which includes PFDN1 assists in the proper folding of actin and tubulin proteins. This complex functions as a co-chaperone directing unfolded proteins to the cytosolic chaperonin TriC/CCT complex for further refolding. By interacting with actin and tubulin PFDN1 ensures that key structural proteins maintain their integrity and availability for cellular functions. This interaction plays a critical role in cytoskeleton dynamics affecting cellular shape and movement.
Pathways
PFDN1 plays a significant role in the protein folding pathway and the regulation of actin cytoskeleton pathway. Within these pathways PFDN1 helps coordinate with other proteins such as TCP1 part of the TriC/CCT complex. This cooperation ensures efficient protein maturation and structural arrangement within cells. The correct functioning of these pathways relies on well-folded actin and tubulin proteins impacting cellular architecture and intracellular transport mechanisms.
Malfunction of PFDN1 can contribute to neurodegenerative diseases and cancer. The disruption of proper protein folding might result in aggregates characteristic of neurodegenerative conditions. Proteins like APOE have been studied in relation to how PFDN1 disruptions might contribute to neurodegenerative disease pathways. In cancer altered PFDN1 expression affects cell proliferation and survival. This alteration connects with oncogenes and tumor suppressor genes influencing tumor growth and progression. Understanding these associations provides insight into the therapeutic targeting of PFDN1 in disease contexts.