Abcam, ab151996, Anti-CYP2J2 antibody

Size: 100µL
Rabbit Polyclonal CYP2J2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Cytochrome P450 2J2 aa 200-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Cytochrome P450 2J2 aa 200-500. The exact immunogen used to generate this antibody is proprietary information.P51589

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYP2J2 also known as cytochrome P450 2J2 is an enzyme belonging to the cytochrome P450 superfamily. It catalyzes the metabolism of arachidonic acid to epoxyeicosatrienoic acids (EETs) which are signalling molecules. CYP2J2 has a mass of approximately 57 kDa and is prominently expressed in the heart although expression also occurs in the liver intestine and other organs. The enzyme's activity involves the oxidation of various substrates including certain drugs contributing to their metabolism and elimination.
Biological function summary
CYP2J2 contributes to cardiovascular function regulation by producing EETs. EETs have anti-inflammatory and vasodilatory effects which maintain vascular health. This enzyme does not usually form part of larger complexes but can influence other biological processes independently. The regulation of blood pressure and prevention of inflammation highlight the vascular role of CYP2J2 through EETs.
Pathways
CYP2J2 plays a significant role in the arachidonic acid cascade. This pathway involves the conversion of arachidonic acid into various eicosanoids each with distinct biological functions. CYP2J2 directly interacts with arachidonic acid modifying it into EETs differing from the action of other cytochrome P450 enzymes like CYP2C8. These enzymes collaboratively participate in complex lipid signalling pathways which maintain cardiovascular health and homeostasis.
CYP2J2 has a role in cardiac disorders such as ischemia and hypertension. Increased activity or expression of CYP2J2 can provide protective effects against cardiac injury due to the vasodilatory and anti-inflammatory properties of EETs. Related proteins like CYP2C9 also participate in similar roles but with distinct regional effects in tissues. Variations in CYP2J2 expression or mutations can influence susceptibility to cardiovascular diseases highlighting its potential as a therapeutic target.