Abcam, ab152135, Anti-DOM3Z antibody

Size: 100µL
Rabbit Polyclonal DOM3Z antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DXO aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DXO aa 1-250. The exact immunogen used to generate this antibody is proprietary information.O77932

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DOM3Z also known as exosome component 1 or hDOM3Z is a protein involved in RNA processing and degradation. It has a molecular mass of about 28 kDa. This protein is present in various tissues with higher expression levels seen in the heart and skeletal muscle. DOM3Z localizes to the nucleus where it plays an important role in maintaining RNA quality control. The protein acts within the RNA exosome complex which is a multi-protein complex essential for RNA decay.
Biological function summary
DOM3Z forms part of the RNA exosome complex working in concert with other components to remove defective or unnecessary RNA molecules. This activity is essential for regulating RNA homeostasis and ensuring the fidelity of RNA populations within the cell. By interacting with exosome core components and exosome co-factors DOM3Z facilitates the degradation of a wide range of RNA substrates including messenger RNA and non-coding RNA. The proper function of DOM3Z within the exosome complex assures accuracy in gene expression regulation.
Pathways
The RNA degradation pathway heavily relies on functions executed by DOM3Z. It interacts with related proteins such as RRP6 and RRP44 within the exosome assembly. Another significant pathway involving DOM3Z is the non-coding RNA processing pathway where its involvement ensures the correct biogenesis and maturation of small nuclear RNAs and small nucleolar RNAs. This involvement of DOM3Z and its associated proteins highlights its central role in maintaining cellular RNA integrity and gene expression equilibrium.
Abnormalities in DOM3Z function correlate with neuromuscular disorders reflecting its higher expression levels in muscle tissues. Mutations or misregulation that affect DOM3Z can also relate to certain types of cancer where disrupted RNA processing leads to uncontrolled cell proliferation. In the context of these conditions DOM3Z interacts with several proteins like DIS3L2 which play roles in disease mechanisms. Understanding and investigating these associations may offer new avenues for therapeutic strategies targeting RNA metabolism disorders.