Abcam, ab152456, Recombinant Human HOXB8 protein

Size: 10µg
Recombinant Human HOXB8 protein is a Human Fragment protein, in the 16 to 114 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:Tag free,
Applications:WB, SDS-PAGE, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P17481,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HOXB8 or Homeobox B8 functions as a transcription factor involved in regulating gene expression during embryonic development. It belongs to the homeobox gene family and plays a critical role in the specification of body pattern. HOXB8 has an approximate mass of 26 kilodaltons. This protein primarily expresses in various tissues including the central nervous system where it contributes to the development of structures in the hindbrain and spinal cord.
Biological function summary
HOXB8 influences the development of structures along the anterior-posterior axis by controlling the expression of downstream target genes. It forms part of the larger HOX complex a group of related proteins that coordinate the development of specific body parts during the embryogenesis. HOXB8 guides the segmentation process ensuring proper differentiation of cells in particular regions of the embryo. Its function is essential for maintaining the appropriate patterning in vertebrate limbs and neural tissues.
Pathways
The contributions of HOXB8 come into focus through its involvement in the Hox gene regulatory network. It plays an important role in regulating important pathways such as the Wnt signaling pathway and the retinoic acid signaling pathway. Within these pathways HOXB8 interacts with other HOX proteins and transcription factors to modulate gene activity necessary for morphogenesis. The coordination within these pathways ensures successful embryonic development by managing complex gene expression related to positional identity.
HOXB8's malfunction associates with specific conditions like leukemia and obsessive-compulsive disorder (OCD). Abnormal expression of HOXB8 has been linked to acute myeloid leukemia where transcriptional dysregulation alters normal cell growth. In the case of OCD studies suggest that disruption in HOXB8 expression correlates with aberrant neural development potentially through its interactions with other neural-related proteins. Understanding these disease associations highlights the importance of HOXB8 in developmental biology and provides insights into potential therapeutic targets.