Abcam, ab153213, Recombinant Human Phospholipase C beta 1/PLCB1 protein

Size: 10µg
Recombinant Human Phospholipase C beta 1/PLCB1 protein is a Human Fragment protein, in the 1107 to 1216 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9NQ66,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Product details:
This product was previously labelled as Phospholipase C beta 1.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Phospholipase C beta 1 (PLCB1) also known as PLC-β1 or PLCB1 is an enzyme involved in intracellular signal transduction. With a molecular weight of around 150 kDa PLCB1 hydrolyzes phosphatidylinositol 45-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG). This biochemical activity plays an important role in the release of calcium ions from intracellular stores. PLCB1 is expressed in regions of the brain including the cerebral cortex as well as in other tissues.
Biological function summary
Multiple functions depend on the signaling cascades initiated by PLCB1. It belongs to a larger family of phospholipase C enzymes contributing to the regulation of various neural processes. The enzyme acts within multiprotein complexes that modulate intracellular calcium levels influencing neuronal activity and synaptic transmission. This role implicates PLCB1 in modulating brain functions related to learning and memory.
Pathways
PLCB1 contributes to cellular signaling pathways such as the phosphoinositide signaling pathway and the G protein-coupled receptor (GPCR) pathway. In these pathways PLCB1 interacts with major proteins such as Gαq subunit of G proteins which activates it. These interactions place PLCB1 as a central player in the pathways that help convert extracellular signals into intracellular actions often involving the regulation of secondary messengers like IP3 and DAG.
Researchers associate PLCB1 with neurological and psychiatric conditions including epilepsy and bipolar disorder. Dysregulation in PLCB1 activity links to altered calcium signaling which can affect brain function. Additionally proteins like Gαq and other GPCR pathway elements may either buffer or exacerbate effects arising from PLCB1 anomalies suggesting molecular interdependencies in related disease mechanisms.