Abcam, ab15348, Anti-ACE2 antibody

Size: 100µg
Anti-ACE2 antibody (ab15348) is a rabbit polyclonal antibody detecting ACE2 in Western Blot, IHC-P, IHC-Fr, ICC/IF, ELISA . Suitable for Bat, Cat, Ferret, Human, Macaque monkey, Mouse, Rat . - Over 230 publications - Trusted since 2004
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human, Cat, Ferret, Macaque monkey, Bat,
Applications:WB, IHC-P, ELISA, IHC-Fr, IHC (PFA fixed), ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ACE2 aa 750 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BYF1,
Specificity:No cross reactivity to ACE1.

Product details:
Product Specifications
Anti-ACE2 antibody (ab15348) is a rabbit polyclonal antibody and is validated for use in ELISA, ICC/IF, IHC (PFA fixed), IHC-Fr, IHC-P, WB in bat, cat, ferret, human, macaque monkey, mouse, rat samples.
Anti-ACE2 antibody (ab15348) specifically detects ACE2 (UniProt ID: Q9BYF1; Molecular weight: 91kDa) and is sold in 100 µg selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-ACE2 antibody (ab15348) has high sensitivity and specificity.
Anti-ACE2 antibody (ab15348) has been cited over 235 times in peer reviewed journals and is trusted by the scientific community.
Anti-ACE2 antibody (ab15348) has 13 independent reviews from customers.
Target Information
ACE2 (angiotensin-converting enzyme 2) is a crucial receptor for the SARS-CoV-2 virus, facilitating its entry into host cells and contributing to COVID-19 pathogenesis. Beyond COVID-19, ACE2 is involved in regulating the renin-angiotensin system, impacting blood pressure and inflammation, and is being explored as a therapeutic target for various infectious diseases. For instance, ACE2 has been implicated in the pathogenesis of SARS (Severe Acute Respiratory Syndrome) caused by the SARS-CoV virus, which also uses ACE2 as a receptor to enter host cells. Additionally, ACE2 expression and activity are being studied in the context of other viral infections, such as influenza and certain types of viral pneumonia, where it may influence disease severity and outcomes

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ACE2 protein also known as angiotensin-converting enzyme 2 is an essential component in the renin-angiotensin system. It functions mechanically by converting the hormone angiotensin II to angiotensin-(1-7) which helps regulate blood pressure and fluid balance. The molecular weight of ACE2 is approximately 120 kDa. This protein is expressed in various tissues particularly the lungs heart kidneys and gastrointestinal tract. In cultured cells like Caco-2 cells researchers often study this expression.
Biological function summary
The ACE2 protein plays an important role in the regulation of cardiovascular and renal functions. It is a single-pass type I membrane protein and its activity reduces inflammation and oxidative stress in cells. ACE2 does not function as part of a larger protein complex but its enzymatic conversion has a substantial impact on reducing the effects of angiotensin II in the body leading to vasodilation and decreased blood pressure.
Pathways
ACE2 involvement is significant in the renin-angiotensin system and the kallikrein-kinin system. These pathways are essential for maintaining cardiovascular homeostasis. In the renin-angiotensin system ACE2 works in opposition to angiotensin-converting enzyme (ACE) balancing the effects through the production of angiotensin-(1-7) from angiotensin II. Additionally ACE2 interacts indirectly with proteins like angiotensin receptor type 1 (AT1) and angiotensin receptor type 2 (AT2) ensuring proper signaling and physiological responses.
ACE2 links closely with conditions such as hypertension and COVID-19. Increased activity of angiotensin II due to low ACE2 levels contributes to hypertension. In infectious disease SARS-CoV-2 virus responsible for COVID-19 uses ACE2 as an entry receptor to initiate infection in host cells. This interaction highlights the importance of ACE2 in disease pathogenesis and has prompted interest in ACE2 as a potential therapeutic target.