Abcam, ab153509, Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein

Size: 10µg
Recombinant Human Adiponectin Receptor 2/ADIPOR2 protein is a Human Full Length protein, in the 1 to 386 aa range, expressed in Wheat germ, suitable for ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q86V24,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione

Product details:
This product was previously labelled as Adiponectin Receptor 2.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Adiponectin Receptor 2 also known as ADIPOR2 or the adiponectin receptor is an integral membrane protein responsible for mediating the effects of adiponectin a hormone involved in regulating glucose and fatty acid metabolism. ADIPOR2 has a mass of about 39 kDa. It is predominantly expressed in skeletal muscle and liver tissues. The receptor plays a critical role in energy homeostasis and glucose regulation by binding to adiponectin which facilitates the activation of downstream signaling pathways.
Biological function summary
ADIPOR2 influences energy balance and lipid metabolism. It is not part of a larger protein complex but functions in concert with another receptor Adiponectin Receptor 1 (ADIPOR1). The action of ADIPOR2 helps to enhance insulin sensitivity and fatty acid oxidation. The receptor also contributes to the regulation of metabolic rate and glucose uptake in the liver and muscle tissues supporting overall metabolic health.
Pathways
ADIPOR2 connects to important metabolic routes such as the AMP-activated protein kinase (AMPK) pathway and the peroxisome proliferator-activated receptor alpha (PPARα) pathway. These pathways are important for cellular energy management and metabolic adaptation. ADIPOR2 cooperates with proteins like AMPK and PPARα to regulate lipid and glucose metabolism contributing to increased insulin sensitivity and efficient energy use in cells.
ADIPOR2 has links to conditions such as type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The receptor’s role in enhancing insulin sensitivity and promoting fatty acid oxidation makes it a significant target for understanding and potentially treating these metabolic disorders. Additionally its connection with proteins like AMPK suggests that manipulating ADIPOR2 activity could offer therapeutic benefits for managing insulin resistance and fatty liver-associated diseases.