Abcam, ab153802, Anti-GAPDS antibody

Size: 100µL
Rabbit Polyclonal GAPDS antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GAPDHS aa 150-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GAPDHS aa 150-400. The exact immunogen used to generate this antibody is proprietary information.O14556

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GAPDS also known as glyceraldehyde-3-phosphate dehydrogenase-sperm is an important enzyme involved in glycolytic processes. The protein usually references a mass of about 44 kDa. Expressed mainly in testicular cells and spermatozoa GAPDS is important for energy production during spermatogenesis and sperm motility. It shares sequence similarity with GAPDH making it an isoform within the same enzymatic family.
Biological function summary
GAPDS plays a critical role in glycolysis serving as an important enzyme that facilitates the conversion of glyceraldehyde-3-phosphate to 13-bisphosphoglycerate. GAPDS can function in complex with other glycolytic enzymes helping generate ATP which is necessary for sperm cell functions. GAPDS expression supports processes essential for male fertility specifically through its involvement in energy supply to sperm flagella.
Pathways
GAPDS is a part of the glycolysis metabolic pathway which is essential for ATP production in sperm. In this pathway it works closely with other glycolytic enzymes like phosphoglycerate kinase and enolase ensuring the continuous flow of energy. GAPDS also indirectly connects to the respiratory chain as glycolytic byproducts feed into mitochondrial oxidative phosphorylation allowing integrated energy metabolism.
GAPDS has implications in male infertility particularly when there is abnormal sperm motility. Defects or deficiencies in GAPDS can impair ATP production in sperm leading to suboptimal motility and reduced fertility. The protein might also have a connection with certain metabolic disorders that affect energy production like glycolytic enzyme deficiencies where similar pathways involving proteins like GAPDH might show concurrent dysfunctions.