Abcam, ab153828, Anti-Aldolase B antibody

Size: 100µL
Rabbit Polyclonal Aldolase B antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ALDOB aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ALDOB aa 1-300. The exact immunogen used to generate this antibody is proprietary information.P05062

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Aldolase B also known as fructose-bisphosphate aldolase B is an enzyme critical in fructose metabolism. It facilitates the cleavage of fructose-16-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate both vital intermediates in glycolysis and gluconeogenesis. Aldolase B has a molecular mass of approximately 39 kDa. It is expressed mainly in the liver with lower levels found in the kidneys and intestines.
Biological function summary
This enzyme plays an important role in the breakdown of dietary sugars. The primary biological role of aldolase B is its function in the liver-specific pathway of fructose catabolism. It does not function as part of a large multiprotein complex but operates as a homotetramer. Aldolase B's activity helps to regulate blood sugar levels and manage energy sources especially when glucose is not readily available.
Pathways
Aldolase B is involved in the gluconeogenesis and glycolysis pathways. In gluconeogenesis it helps in the formation of glucose from non-carbohydrate sources which is important during fasting states. In glycolysis it aids in the breakdown of glucose to produce energy. This enzyme therefore interacts with other glycolytic enzymes such as phosphofructokinase and pyruvate kinase which are part of the same metabolic pathways.
Defects in aldolase B activity can lead to hereditary fructose intolerance a potentially serious condition caused by the inability to properly metabolize fructose. This disorder often results in symptoms such as hypoglycemia and jaundice following fructose ingestion. The disorder can also relate to liver and kidney dysfunctions as these organs express aldolase B most prominently. Deficient aldolase B function disrupts the metabolic pathways where the enzyme interacts with other important proteins and enzymes involved in energy balance.