Abcam, ab153849, Anti-DECR2/PDCR antibody

Size: 100µL
Rabbit Polyclonal DECR2/PDCR antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DECR2 aa 50-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DECR2 aa 50-250. The exact immunogen used to generate this antibody is proprietary information.Q9NUI1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DECR2 also known as 24-dienoyl-CoA reductase 2 involves in fatty acid metabolism by catalyzing the reduction of unsaturated acyl-CoA compounds. It acts mechanically within the mitochondria allowing the breakdown of polyunsaturated fatty acids. DECR2 weighs approximately 37 kDa and has widespread expression mainly found in tissues with high energy demand like liver heart and muscle.
Biological function summary
DECR2 facilitates the β-oxidation of unsaturated fatty acids therefore supporting energy production. As part of lipid metabolism it helps to maintain cellular energy balance and influences overall energy homeostasis. This enzyme does not form a complex but interacts with other mitochondrial enzymes to synchronize fatty acid degradation processes allowing cells to utilize stored fats efficiently.
Pathways
DECR2 integrates into the fatty acid oxidation pathway which links to energy metabolism pathways providing substrates for ATP production. This enzyme collaborates closely with other molecules like acyl-CoA dehydrogenases and enoyl-CoA isomerases within these pathways. This collaboration ensures the complete breakdown of unsaturated fatty acids influencing both energy production and mitochondrial function.
DECR2 plays an important role in conditions like metabolic syndrome and mitochondrial fatty acid β-oxidation disorders. Abnormalities or deficiencies in its function may contribute to energy metabolism defects impacting cellular energy balance and mitochondrial health. DECR2's activity can associate with other proteins involved in these conditions such as long-chain acyl-CoA dehydrogenase (LCAD) highlighting the need for this enzyme in maintaining metabolic health.