Abcam, ab153951, Anti-GNA11 antibody

Size: 100µL
Rabbit Polyclonal GNA11 antibody. Suitable for WB and reacts with Human, Rat, Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GNA11 aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GNA11 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P29992

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GNA11 also known as G-protein subunit alpha-11 is a protein that functions mechanically within cells as part of the G protein family. This protein plays a role in transmitting signals from the surface of the cell to its interior. GNA11 has a molecular mass of approximately 42 kDa and it is mainly expressed in various tissues including the heart and central nervous system. It operates by interacting with receptors on the cell surface instigating conformational changes that initiate intracellular signaling cascades.
Biological function summary
G-protein subunit alpha-11 interacts with several signaling molecules and works predominantly as part of a heterotrimeric G protein complex. This protein complex plays an important role in modulating a variety of biological processes such as cardiovascular function and neuronal signaling. GNA11 contributes to cellular responses by activating downstream effectors which can influence cellular growth differentiation and response to external stimuli.
Pathways
G-protein subunit alpha-11 is an essential component of the phosphoinositide signaling pathway. It assists in the conversion of extracellular signals into intracellular action by facilitating the release of secondary messengers like inositol trisphosphate. In this pathway it works closely with other proteins like GNAQ and GNA15 which share similar mechanistic roles. Through these interactions GNA11 regulates calcium mobilization and protein kinase C activity impacting various cellular functions.
GNA11 mutations have links to certain conditions like uveal melanoma and hypocalcemia. These mutations alter the normal signaling pathways and can lead to unregulated cell growth as seen in cancer. Uveal melanoma relates to GNA11 through mutations that activate signaling pathways uncontrollably. Similarly in hypocalcemia the GNA11 protein associates with the calcium-sensing receptor which causes imbalances in calcium homeostasis. These associations highlight the significance of GNA11 in pathology as well as signaling pathways.