Abcam, ab153995, Anti-GSTZ1 antibody

Size: 100µL
Rabbit Polyclonal GSTZ1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GSTZ1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GSTZ1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O43708

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GSTZ1 also known as Glutathione S-Transferase Zeta 1 is an enzyme that plays an important role in the metabolism of various chemical compounds. It has a molecular mass of approximately 34 kDa. GSTZ1 is ubiquitously expressed in many tissues with significant levels in the liver kidney and heart. This enzyme is part of the GST family which contributes to detoxification processes by conjugating reduced glutathione to various substrates.
Biological function summary
GSTZ1 participates in the breakdown of amino acids specifically in the catabolic pathway of L-phenylalanine and L-tyrosine. The enzyme assists in the production of maleylacetoacetate and its isomerization to fumarylacetoacetate an essential step in the phenylalanine and tyrosine catabolism. GSTZ1 does not form part of a larger multi-protein complex but its function is critical in maintaining cellular homeostasis by preventing the accumulation of potentially toxic intermediates.
Pathways
GSTZ1 integrates into the metabolic pathway that includes glutathione metabolism and the phenylalanine and tyrosine degradation pathway. It interacts functionally with other enzymes like Fumarylacetoacetate hydrolase (FAH) and Phenylalanine hydroxylase (PAH) playing roles in sequential catalysis steps. These pathways are vital for maintaining amino acid balance and detoxification of byproducts within the organism.
GSTZ1 has been linked to metabolic disorders like Tyrosinemia type I and various forms of cancer. Tyrosinemia type I a disorder caused by defects in tyrosine metabolism directly implicates GSTZ1 as an important player in managing toxic intermediates. Additionally altered expression of GSTZ1 has been observed in different cancer types suggesting its potential role in tumorigenesis. FAH related through the Tyrosinemia disorder represents another key protein that GSTZ1 activity impacts highlighting its disease association.