Abcam, ab154181, Anti-SCAMP2/SC2 antibody [EPR10185]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SCAMP2/SC2 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR10185,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCAMP2 also known as SC2 is a small protein with a mass of approximately 33 kDa. It plays a role in secretory vesicle trafficking. SCAMP2 is widely expressed in various tissues including high levels in brain and endocrine tissues. This protein is embedded in the membrane of secretory vesicles which suggests an involvement in membrane trafficking processes. SCAMP2 possesses features such as coiled-coil domains important for intracellular trafficking functions.
Biological function summary
SCAMP2 is part of the intricate machinery regulating vesicle fusion and exocytosis. The protein participates in the transportation of vesicles between cell compartments ensuring the delivery of proteins and lipids to their target sites. SCAMP2 often functions as part of a larger complex involving other SCAMP family members enhancing vesicle recycling and secretion process efficiency. It regulates synaptic vesicle exocytosis which is essential for neurotransmitter release in the nervous system.
Pathways
The actions of SCAMP2 are integral in intracellular transport and exocytosis pathways. It interacts with SNARE proteins which are critical components of the membrane fusion machinery. SCAMP2 aids in coordinating the recruitment and assembly of SNARE complexes thereby facilitating efficient vesicle docking and fusion during neurotransmitter release. By engaging with proteins like syntaxin and VAMP2 SCAMP2 ensures proper communication between neurons playing an important role in synaptic transmission.
SCAMP2 is linked to neurological conditions such as epilepsy and neurodegenerative disorders. Alterations in SCAMP2 expression or function may affect synaptic transmission which can disrupt neural network stability and lead to disease states. It interacts with other neuronal proteins like synapsin and synaptophysin which may contribute to the development or progression of these conditions. Understanding SCAMP2's role can provide insight into therapeutic approaches for epilepsy and other related disorders.