Abcam, ab154675, Anti-NRIP antibody

Size: 100µL
Rabbit Polyclonal NRIP antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DCAF6 aa 350-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DCAF6 aa 350-700. The exact immunogen used to generate this antibody is proprietary information.Q58WW2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Nuclear Receptor Interacting Protein (NRIP) also known as NRIP1 or RIP140 is an essential coregulator in gene expression. It weighs about 115 kDa and interacts with various nuclear receptors. Scientists find NRIP expression in several tissues including the heart skeletal muscle and adipose tissue indicating its broad influence on biological function. Its mechanical role involves modulation of transcriptional activities by interacting with other proteins and DNA.
Biological function summary
NRIP influences energy homeostasis and reproductive processes. It forms part of transcriptional complexes with nuclear receptors aiding in regulating genes involved in lipid metabolism and glucose homeostasis. NRIP's involvement extends to the reproductive system where it affects the expression of genes required for fertility. The protein's role in these processes marks its importance in the regulation of fundamental biological functions.
Pathways
NRIP plays a role in lipid metabolism and energy balance pathways. It interacts within the peroxisome proliferator-activated receptor (PPAR) and estrogen receptor pathways influencing cellular energy status and fat storage. Proteins like PPARα and PPARγ show close relations with NRIP in these pathways where NRIP acts as a coregulator to fine-tune gene expression that controls fatty acid oxidation and adipogenesis.
NRIP's disruption links to metabolic syndromes and infertility. Misregulation of NRIP influences conditions like obesity and type 2 diabetes highlighting its role in energy balance. Additionally NRIP's connection with estrogen receptors ties it to reproductive disorders where altered expression patterns can lead to fertility issues. Understanding NRIP interactions with proteins like estrogen receptors can provide insights into therapeutic targets for related diseases.