Abcam, ab154798, Anti-ClC-2 antibody [EPR6492(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal ClC-2 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR6492(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ClC-2 or chloride channel 2 is a voltage-gated chloride channel found in the cell membranes. It belongs to the CLC family of chloride channels and transporters weighing approximately 97 kDa. The expression of ClC-2 can be seen in various tissues throughout the body with high levels observed in the brain and intestinal epithelial cells. ClC-2 functions mechanically by facilitating the passive flow of chloride ions across the cell membrane therefore influencing the membrane potential and cellular excitability.
Biological function summary
Chloride channel 2 plays an important role in maintaining cell volume and electrical stability. By regulating the flow of ions ClC-2 supports processes such as signal transmission in neurons and hydration in the bowel. While not directly part of a larger complex its function is influenced by interactions with other membrane proteins which help modulate its activity under different physiological conditions.
Pathways
Chloride channel 2 is involved in cellular processes including the epithelial transport of ions and neuronal signaling pathways. Within the gastrointestinal tract ClC-2 participates in the signaling pathway that maintains fluid balance and absorption. It also interacts with proteins like CFTR to ensure proper ion transport which is particularly important under conditions that stimulate chloride secretion.
Chloride channel 2 has been associated with conditions such as epilepsy and chloride diarrhea. Mutations or dysregulation of ClC-2 can lead to defective ion homeostasis. In epilepsy abnormal ClC-2 function may contribute to neuronal hyperexcitability. Furthermore the relationship between ClC-2 and CFTR is implicated in chloride diarrhea where impaired chloride transport affects intestinal fluid secretion.