Abcam, ab154802, Anti-MNAT1 antibody [EPR2555(2)]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal MNAT1 antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human, Mouse samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2555(2),
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein MNAT1 also known as menage à trois 1 functions as a component of the CDK-activating kinase complex. It weighs about 32 kilodaltons. MNAT1 plays a role in regulating cell cycle progression. It expresses widely in various tissues but shows higher levels in proliferating tissues due to its involvement in cell division. Its expression pattern suggests a significant function in maintaining proper cell cycle control.
Biological function summary
This protein serves as a regulatory subunit of the CDK7-cyclin H-MNAT1 complex. This complex forms the core of CDK-activating kinase which is essential for the activation of other cyclin-dependent kinases (CDKs). By doing so MNAT1 influences transcription regulation and DNA repair processes. As part of this complex MNAT1 modulates the activity of the proteins involved in a variety of cellular mechanisms. Through these activities MNAT1 helps in maintaining genomic integrity and proper cellular response to DNA damage.
Pathways
The activity of MNAT1 is involved in the cell cycle regulation pathway and the transcription regulation process. It plays a role in phosphorylating other CDKs directly influencing their activation and consequently cell cycle control. MNAT1 associates closely with proteins such as cyclin H and CDK7 within these pathways. This collaboration ensures that the essential checkpoints in the cell cycle are correctly regulated and that transcription processes are executed properly.
Irregularities in MNAT1 function can correlate with cancer development due to its central role in cell cycle regulation and genomic stability. Altered expression levels or mutations in MNAT1 can disrupt normal cell division leading to unchecked cell proliferation. Furthermore MNAT1 interacts with cyclin H and CDK7 which are also important in the proper regulation of cell cycle checkpoints and can also influence cancer pathways when dysfunctional. Hence MNAT1 is a potential target for therapeutic strategies aiming to control abnormal cell growth.